A preliminary
immunopharmacological study of an antiendometriotic
herbal medicine, Keishi-bukuryo-gan
Acupuncture, Infertility, & IVF Research - Abstract Articles
Tanaka T; Mizuno K; Umesaki N; Ogita S Department of
Obstetrics & Gynecology, Osaka City University Medical
School, Japan.
Osaka City Med J,
44(1):117-24 1998 Jun (ISSN: 0030-6096)
Changes in the specific
antiendometrial IgM antibodies in an endometriotic
patient, who were treated with leuproride acetate and in
turn with Keishi-bukuyogan, were investigated by the
flowcytometric analysis which was developed in our
laboratory. The oriental therapy decreased the specific
IgM antibody titer gradually and kept the patient
symptom-free for more than 7 months without any
suppression of serum CA125 and estradiol levels. On the
other hand, leuproride acetate therapy suppressed both
serum CA125 and serum estradiol levels but not the IgM
antibody titer. The results suggest that the specific
antiendometrial IgM autoantibody could be a pathogenic
molecule in endometriosis and it could also serve as a
clinical marker for the oriental therapy of
endometriosis.
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